Biot - 2009
نویسندگان
چکیده
The analysis of high-throughput data sets, such as microarray data, often requires that individual variables (genes, for example) be grouped into small clusters such that all the variables in any given cluster have highly correlated values across all samples. Gene shaving is an established method for generating such clusters, but is overly sensitive to the input data: changing one sample out of hundreds can determine whether or not an entire cluster is found, even if the search is continued for many hundreds of clusters. This paper describes a clustering method based on the bootstrap aggregation (bagging) of gene shaving clusters, which overcomes this and other problems. The paper also describes the application of the new method to a large meta-data set of gene expression microarray data from brain tumor samples.
منابع مشابه
MOX–Report No. 12/2009 Coupling Biot and Navier-Stokes equations for modeling fluid-poroelastic media interaction
The interaction between a fluid and a poroelastic structure is a complex problem that couples the Navier-Stokes equations with the Biot system. The finite element approximation of this problem is involved due to the fact that both subproblems are indefinite. In this work, we first design residual-based stabilization techniques for the Biot system, motivated by the variational multiscale approac...
متن کاملCoupling Biot and Navier-Stokes problems for fluid-poroelastic structure interaction
The interaction between a fluid and a poroelastic structure is a complex problem that couples the Navier-Stokes equations for the fluid with the Biot system for the structure. The finite element approximation of this problem is involved due to the fact that both subproblems are indefinite. In this work, we design residual-based stabilization techniques for the Biot system, that have been motiva...
متن کاملLarge-Biot-number non-isothermal flow of a thin film on a stationary or rotating cylinder
Using the lubrication approximation we investigate two-dimensional steady flow of a thin film of fluid with temperature-dependent viscosity on a uniformly heated or cooled horizontal cylinder, which may be stationary or rotating about its axis, in the case when the Biot number (a measure of heat transfer at the free surface) is large. We show that the film thickness (but not the fluid velocity)...
متن کاملThe Biot-savart Operator and Electrodynamics on Subdomains of the Three-sphere
ABSTRACT. We study the generalization of the Biot-Savart law from electrodynamics in the presence of curvature. We define the integral operator BS acting on all vector fields on subdomains of the three-dimensional sphere. By doing so, we establish a geometric setting for electrodynamics in positive curvature. When applied to a vector field, the BiotSavart operator behaves like a magnetic field;...
متن کاملThe effects of serum testosterone, estradiol, and sex hormone binding globulin levels on fracture risk in older men.
CONTEXT The relationship between sex steroids and fracture is poorly understood. OBJECTIVE The objective of the study was to examine associations between nonvertebral fracture risk and bioavailable estradiol (bioE2), bioavailable testosterone (bioT), and SHBG. DESIGN This was a case-cohort study. SETTING The Osteoporotic Fractures in Men Study (MrOS) was conducted in a prospective U.S. co...
متن کاملMarangoni Convection in a Fluid Saturated Porous Layer with a Deformable Free Surface
The stability analysis of Marangoni convection in porous media with a deformable upper free surface is investigated. The linear stability theory and the normal mode analysis are applied and the resulting eigenvalue problem is solved exactly. The Darcy law and the Brinkman model are used to describe the flow in the porous medium heated from below. The effect of the Crispation number, Bond number...
متن کامل